UNIVERSITY OF FLORIDA

ufSeal

Computational Neuromechanics Lab

B.J. FREGLY, PH.D.
KNOX T. MILLSAPS
PROFESSOR, AND
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION PROFESSOR

Seeking to make "computational neurorehabilitation"
a clinical reality for the design of personalized treatments for movement impairments.

toppanelgradient

Walking motion predicted for a hemiparetic subject using a subject-specitic computational model controlled by five muscle synergies per leg (Meyer et al., Frontiers in Bioengineering and Biotechnology, 2016)

*Graduate student/post-doctoral fellow supervised by Dr. Fregly
§High school student supervised by Dr. Fregly
Corresponding author

Journal Articles

Web of Science Times cited: 2559, Average citations per item: 35.05, h-index: 28

1. Bianco, N.A.*, Patten, C., and Fregly, B.J.† (2016) Can measured muscle synergies construct unmeasured muscle excitations? Journal of Biomechanical Engineering (in review).
(Download PDF file)

2. Meyer, A.J.*, Eskinazi, I.*, Jackson, J.N.*, Rao, A.V., Patten, C., and Fregly, B.J.† (2016) Muscle synergies facilitate computational prediction of subject-specific walking motions. Frontiers in Bioengineering and Biotechnology 4, 77.
(Download PDF file)

3. Meyer, A.J.*, Patten, C., and Fregly, B.J.† (2016) Lower extremity EMG-driven modeling of walking with automated adjustment of musculoskeletal geometry. PLOS ONE (in review).
(Download PDF file)

4. De Groote, F.*†, Kinney, A.L.*, Rao, A.V., and Fregly, B.J. (2016) Evaluation of direct collocation optimal control problem formulations for solving the muscle redundancy problem. Annals of Biomedical Engineering 44, 2922-2236.
(Download PDF file)

5. Eskinazi, I.* and Fregly, B.J.† (2016) An open-source toolbox for surrogate modeling of joint contact mechanics. IEEE Transactions on Biomedical Engineering 63, 269-277 (featured article on journal website).
(Download PDF file)

6. Jackson, J.N.*, Hass, C.J., and Fregly, B.J.† (2016) Development of a subject-specific foot-ground contact model for gait. Journal of Biomechanical Engineering 138, 091002 (12 pages).
(Download PDF file)

7. Serrancolí, G.*, Kinney, A.L.*, Fregly, B.J., and Font-Llagunes, J.M.† (2016) Neuromusculoskeletal model calibration significantly affects accuracy of predicted knee contact forces for walking. Journal of Biomechanical Engineering 138, 081001 (11 pages).
(Download PDF file)

8. Eskinazi, I.* and Fregly, B.J.† (2015) Surrogate modeling of deformable joint contact using artificial neural networks. Medical Engineering & Physics 37, 885-891.
(Download PDF file)

9. Fregly, B.J.†, Fregly, C.D.§, and Kim, B.T.§ (2015) Computational prediction of muscle moments during ARED squat exercise on the International Space Station. Journal of Biomechanical Engineering 137, 121005 (8 pages).
(Download PDF file)

10. Jackson, J.J.*, Hass, C.J., and Fregly, B.J.† (2015) Residual elimination algorithm enhancements to improve foot motion tracking during forward dynamic simulations of gait. Journal of Biomechanical Engineering 137, 111002 (8 pages).
(Download PDF file)

11. Mizu-uchi, H., Colwell, C.W., Flores-Hernandez, C., Fregly, B.J., Matsuda, S., Iwamoto, Y., and D’Lima, D.D.† (2015) Patient-specific computer model of dynamic squatting after total knee arthroplasty. Journal of Arthroplasty 30, 870-874.
(Download PDF file)

12. Pizzolato, C., Lloyd, D.G.†, Sartori, M., Ceseracciu, E., Besier, T.F., Fregly, B.J., and Reggiani, M.† (2015) CEINMS: A toolbox to investigate the influence of different neural solutions on the prediction of muscle excitation and joint moments during dynamic motor tasks. Journal of Biomechanics 48, 3929-3936 (Winner of the 2015 Australian and New Zealand Society of Biomechanics Publication of the Year Award).
(Download PDF file)

13. Walter, J.P.*, Korkmaz, N., Fregly, B.J., and Pandy, M.G.† (2015) Contribution of tibiofemoral joint contact to net loads at the knee in gait. Journal of Orthopaedic Research 33, 1054-1060.
(Download PDF file)

14. Roemmich, R.T., Fregly, B.J., and Hass, C.J.† (2014) Neuromuscular complexity during gait is not responsive to medication in persons with Parkinson's disease. Annals of Biomedical Engineering 42, 1901-1912
(Download PDF file)

15. Walter J.P.*, Kinney, A.L.*, Banks, S.A., D’Lima, D.D., Besier, T.F., Lloyd, D.G., and Fregly, B.J.† (2014) Muscle synergies may improve optimization prediction of knee contact forces during walking. Journal of Biomechanical Engineering 136, 021031 (9 pages).
(Download PDF file)

16. D’Lima, D.D.†, Fregly, B.J., and Colwell, C.W. (2013) Implantable sensor technology: measuring bone and joint biomechanics of daily life in vivo. Arthritis Research and Therapy 15, 203 (8 pages).
(Download PDF file)

17. Gerus, P., Sartori, M., Besier, T.F., Fregly, B.J., Delp, S.L., Banks, S.A., Pandy, M.G., D’Lima, D.D., Lloyd, D.G.† (2013) Subject-specific knee joint geometry improves predictions of medial tibiofemoral contact forces. Journal of Biomechanics 46, 2778-2786.
(Download PDF file)

18. Kinney, A.L.*, Besier, T.F., D'Lima, D.D., and Fregly, B.J.† (2013) Update on grand challenge competition to predict in vivo knee loads. Journal of Biomechanical Engineering 135, 021005 (4 pages).
(Download PDF file)

19. Kinney, A.L.*, Besier, T.F., Silder, A., Delp, S.L., D’Lima, D.D., and Fregly, B.J.† (2013) Changes in in vivo knee contact forces through gait modification. Journal of Orthopaedic Research 31, 434-440.
(Download PDF file)

20. Meyer, A.J.*, D’Lima, D.D., Besier, T.F., Lloyd, D.G., Banks, S.A., Colwell, C.W. Jr., and Fregly, B.J.† (2013) Are external knee load and EMG measures accurate indicators of internal knee contact forces during gait? Journal of Orthopaedic Research 31, 921-929.
(Download PDF file)

21. Pegg, E.C., Walter, J.*, Mellon, S.J., Pandit, H.G., Murray, D.W., D’Lima, D.D., Fregly, B.J., and Gill, H.S.† (2013) Evaluation of factors affecting tibial bone strain after unicompartmental knee replacement. Journal of Orthopaedic Research 31, 821-828.
(Download PDF file)

22. Rodriguez, K., Roemmich R., Cam, B.*, Fregly, B., and Hass, C.† (2013) Persons with Parkinson's disease exhibit decreased neuromuscular complexity during gait. Clinical Neurophysiology 124, 1390-1397.
(Download PDF file)

23. Boninger, M.L.†, Cowan, R.E., and Fregly, B.J. (2012) Structures promoting research, training, and technology transfer in mobility: lessons learned from a visit to European centers. Journal of NeuroEngineering and Rehabilitation 9, 19 (5 pages).
(Download PDF file)

24. Cowan, R.E.†, Fregly, B.J., Boninger, M.L., Chan, L., Rodgers, M.M., and Reinkensmeyer, D.J. (2012) Recent trends in assistive technology for mobility. Journal of NeuroEngineering and Rehabilitation 9, 20 (8 pages).
(Download PDF file)

25. D’Lima, D.D.†, Fregly, B.J., Patil, S., Steklov, N., and Colwell, C.W. (2012) Knee joint forces: prediction, measurement, and significance. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 226, 95-102.
(Download PDF file)

26. Fregly, B.J.† (2012) Gait modification to treat knee osteoarthritis. HSS Journal 8, 45-48.
(Download PDF file)

27. Fregly, B.J.†, Besier, T.F., Lloyd, D.G., Delp, S.L., Banks, S.A., Pandy, M.G., and D’Lima, D.D. (2012) Grand challenge competition to predict in vivo knee loads. Journal of Orthopaedic Research 30, 503-513 (research perspective article featured on journal cover; listed in Web of Science as a Highly Cited Paper “in the top 1% of its academic field based on a highly cited threshold for the field and publication year”).
(Download PDF file)

28. Fregly, B.J.†, Boninger, M.L., and Reinkensmeyer, D.J. (2012) Personalized neuromusculoskeletal modeling to improve treatment of mobility impairments. Journal of NeuroEngineering and Rehabilitation 9, 18 (11 pages).
(Download PDF file)

29. Reinkensmeyer, D.J.†, Bonato, P., Boninger, M.L., Chan, L., Cowan, R.E., Fregly, B.J., and Rodgers. M.M. (2012) Major trends in mobility technology research and development: overview of the results of the NSF-WTEC European study. Journal of NeuroEngineering and Rehabilitation 9, 22 (4 pages).
(Download PDF file)

30. Vincent, K.R.†, Conrad, B.P., Fregly, B.J., and Vincent, H.K. (2012) The pathophysiology of osteoarthritis: a mechanical perspective on the knee joint. Physical Medicine & Rehabilitation 4, S3-S9.
(Download PDF file)

31. Li, L.*, Patil, S., Steklov, N., Bae, W., Temple-Wong, M., D’Lima, D.D., Sah, R.L., and Fregly, B.J.† (2011) Computational wear simulation of patellofemoral articular cartilage during in vitro testing. Journal of Biomechanics 44, 1507-13.
(Download PDF file)

32. Fregly, B.J.†, Marquez-Barrientos, C.*, Banks, S.A., and DesJardins, J.D. (2010) Increased conformity offers diminishing returns for total knee replacement wear. Journal of Biomechanical Engineering 132, 021007.
(Download PDF file)

33. Lin, Y.C.*, Haftka, R.T., Queipo, N.V., and Fregly, B.J.† (2010) Surrogate articular contact models for computationally efficient multibody dynamic simulations. Medical Engineering & Physics 32, 584-594.
(Download PDF file)

34. Lin, Y.C.*, Walter, J.P.*, Banks, S.A., Pandy, M.G., and Fregly, B.J.† (2010) Simultaneous prediction of muscle and contact forces in the knee during gait. Journal of Biomechanics 43, 945-952.
(Download PDF file)

35. Walter, J.P.*, D’Lima, D.D., Colwell, C.W., and Fregly, B.J.† (2010) Decreased knee adduction moment does not guarantee decreased medial contact force during gait. Journal of Orthopaedic Research 28, 1348-1354.
(Download PDF file)

36. Fregly, B.J.† (2009) Design of optimal treatments for neuromusculoskeletal disorders using patient-specific multibody dynamic models. International Journal of Computational Vision and Biomechanics 2, 145-154.
(Download PDF file)

37. Fregly, B.J.†, D’Lima, D.D., and Colwell, C.W. (2009) Effective gait patterns for offloading the medial compartment of the knee. Journal of Orthopaedic Research 27, 1016-1021.
(Download PDF file)

38. Hamai, S., Moro-oka, T., Miura, H., Shimoto, T., Higaki, H., Fregly, B.J., Iwamoto, Y., and Banks, S.† (2009) Knee kinematics in medial osteoarthritis during in vivo weight-bearing activities. Journal of Orthopaedic Research 27, 1555-1561.
(Download PDF file)

39. Kim, H.J, Fernandez, J.W., Akbarshahi, M., Walter, J.P.*, Fregly, B.J., and Pandy. M.G.† (2009) Evaluation of predicted knee-joint muscle forces during gait using an instrumented knee implant. Journal of Orthopaedic Research 27, 1326-1331.
(Download PDF file)

40. Koh, B.-I.*, Reinbolt, J.A.*, George, A.D., Haftka, R.T., and Fregly, B.J.† (2009) Limitations of parallel global optimization for large-scale human movement problems. Medical Engineering & Physics 31, 515-521.
(Download PDF file)

41. Lin, Y.C.*, Queipo, N.V., Haftka, R.T., and Fregly, B.J.† (2009) Two-dimensional surrogate contact modeling for computationally efficient dynamic simulations of total knee replacements. Journal of Biomechanical Engineering 131, 041010.
(Download PDF file)

42. D'Lima, D.D.†, Steklov, N, Fregly, B.J., Banks, S.A., and Colwell, C.W. (2008) In vivo contact stresses during activities of daily living after knee arthroplasty. Journal of Orthopaedic Research 26, 1549-1555.
(Download PDF file)

43. Fregly, B.J.† (2008) Computational assessment of combinations of gait modifications for knee osteoarthritis rehabilitation. IEEE Transactions on Biomedical Engineering 55, 2104-2106.
(Download PDF file)

44. Fregly, B.J.†, Banks, S.A., D’Lima, D.D., and Colwell, C.W. (2008) Sensitivity of knee replacement contact calculations to kinematic measurement errors. Journal of Orthopaedic Research 26, 1173-1179.
(Download PDF file)

45. Fregly, B.J.†, Reinbolt, J.A.*, and Chmielewski, T.L. (2008) Evaluation of a patient-specific cost function to predict the influence of foot path on the knee adduction torque during gait. Computer Methods in Biomechanics and Biomedical Engineering 11, 63-71.
(Download PDF file)

46. Moro-oka, T., Hamai, S., Miura, H., Shimoto, T., Higaki, H., Fregly, B.J., Iwamoto, Y., and Banks, S.† (2008) Dynamic activity dependence of in vivo normal knee kinematics. Journal of Orthopaedic Research 26, 428-434.
(Download PDF file)

47. Reinbolt, J.A.*, Haftka, R.T., Chmielewski, T.L., and Fregly, B.J.† (2008) A computational framework to predict post-treatment outcome for gait-related disorders. Medical Engineering & Physics 30, 434-443.
(Download PDF file)

48. Schache, A.G.†, Fregly, B.J., Crossley, K.M, Hinman, R.S., and Pandy, M.G. (2008) The effect of gait modification on the external knee adductor moment is reference frame dependent. Clinical Biomechanics 23, 601-608.
(Download PDF file)

49. Verma, N.N., Kolb, E, Cole, B.J., Berkson, E, Garretson, R, Farr, J, and Fregly, B. (2008) The effects of medial meniscal transplantation techniques on intra-articular contact pressures. The Journal of Knee Surgery 21, 20-26.(Download PDF file)

50. Zhao, D.*, Sadoka, H., Sawyer, W.G., Banks, S.A., and Fregly, B.J.† (2008) Predicting knee replacement damage in a simulator machine using a computational model with a consistent wear factor. Journal of Biomechanical Engineering 130, 011004-1 - 011004-10.
(Download PDF file)

51. Fregly, B.J.†, Reinbolt, J.A.*, Rooney, K.L.*, Mitchell, K.H., and Chmielewski, T.L. (2007) Design of patient-specific gait modifications for knee osteoarthritis rehabilitation. IEEE Transactions on Biomedical Engineering 54, 1687-1695.
(Download PDF file)
Download animations below:
Pre-training
Optimization with tighter tracking of pre-training data
Optimization with looser tracking of pre-training data
Post-training with attempted pre-training motion
Post-training with exaggerated optimized motion

52. Moro-oka, T., Hamai, S., Miura, H., Higaki., H., Fregly, B.J., Iwamoto, Y., Banks, S.A.† (2007) Can magnetic resonance imaging-derived bone models be used for accurate motion measurement with single-plane three-dimensional shape registration? Journal of Orthopaedic Research 25, 867-872.
(Download PDF file)

53. Schutte, J.F.*, Haftka, R.T., and Fregly, B.J.† (2007) Improved global convergence probability using multiple independent swarms. International Journal for Numerical Methods in Engineering 71, 678-702.
(Download PDF file)

54. Reinbolt, J.A.*, Haftka, R.T., Chmielewski, T.L., and Fregly, B.J.† (2007) Are patient-specific joint and inertial parameters necessary for accurate inverse dynamics analyses of gait? IEEE Transactions on Biomedical Engineering 54, 782-793.
(Download PDF file)

55. Zhao, D.*, Banks, S.A., D’Lima, D.D., Colwell, C.W., and Fregly, B.J.† (2007) In vivo medial and lateral tibial loads during dynamic and high flexion activities. Journal of Orthopaedic Research 25, 593-602 (Article featured on the cover of this issue).
(Download PDF file)

56. Zhao, D.*, Banks, S.A., Mitchell, K.H., D’Lima, D.D., Colwell, C.W., and Fregly, B.J.† (2007) Correlation between the knee adduction torque and medial contact force for a variety of gait patterns. Journal of Orthopaedic Research 25, 789-797.
(Download PDF file)

57. Zhao, D.*, Sawyer, W.G., and Fregly, B.J.† (2006) Computational wear prediction of UHMWPE in knee replacements. Journal of ASTM International 3, 45-50.
(Download PDF file)

58. Koh, B.-I.*, George, A.D., Haftka, R.T., and Fregly, B.J.† (2006) Parallel asynchronous particle swarm optimization. International Journal for Numerical Methods in Engineering 67, 578-595.
(Download PDF file)

59. Lin, Y.-C.*, Farr, J., Carter, K., and Fregly, B.J.† (2006) Response surface optimization for joint contact model evaluation. Journal of Applied Biomechanics 22, 120-130.
(Download PDF file)

60. Banks, S.A.†, Fregly, B.J., Boniforti, F., Reinschmidt, C., and Romagnoli, S. (2005) Comparing in vivo kinematics of unicondylar and bi-unicondylar knee replacements. Knee Surgery, Sports Traumatology, Arthroscopy 13, 551-556.
(Download PDF file)

61. Fregly, B.J.†, Rahman, H.*, and Banks, S.A. (2005) Theoretical accuracy of model-based shape matching for measuring natural knee kinematics with single-plane fluoroscopy. Journal of Biomechanical Engineering 127, 692-699.
(Download PDF file)

62. Fregly, B.J.†, Sawyer, W.G., Harman, M.K., and Banks, S.A. (2005) Computational wear prediction of a total knee replacement from in vivo kinematics. Journal of Biomechanics 38, 305–314.
(Download PDF file)

63. Hamilton, M.A., Sucec, M.C., Fregly, B.J., Banks, S.A., and Sawyer, W.G.† (2005) Quantifying multidirectional sliding motions in total knee replacements, Journal of Tribology 127, 280-286.
(Download PDF file)

64. Harman, M.K.†, Banks, S.A., Fregly, B.J., Sawyer, W.G., and Hodge, W.A. (2005) Biomechanical mechanisms for damage: Retrieval analysis and computational wear predictions in total knee replacements. Journal of Mechanics in Medicine and Biology 5, 469-475.
(Download PDF file)

65. Reinbolt, J.A.*, Schutte, J.F.*, Fregly, B.J.†, Haftka, R.T., George, A.D., and Mitchell, K.H. (2005) Determination of patient-specific multi-joint kinematic models through two-level optimization. Journal of Biomechanics 38, 621-626.
(Download PDF file)

66. Schutte, J.F.*, Koh, B.-I.*, Reinbolt, J.A.*, Haftka, R.T., George, A.D., and Fregly, B.J.†(2005) Evaluation of a particle swarm algorithm for biomechanical optimization. Journal of Biomechanical Engineering 127, 465-474.
(Download PDF file)
Click here to download Matlab source code for particle swarm optimization

67. Bei, Y.* and Fregly, B.J.† (2004) Multibody dynamic simulation of knee contact mechanics. Medical Engineering & Physics 26, 777-789.
(Download PDF file)

68. Schutte, J.F.*, Reinbolt, J.A.*, Fregly, B.J.†, Haftka, R.T., and George, A.D. (2004) Parallel global optimization with the particle swarm algorithm. International Journal for Numerical Methods in Engineering 61, 2296-2315.
(Download PDF file)

69. Bei, Y.*, Fregly, B.J.†, Sawyer, W.G., Banks, S.A., and Kim, N.H. (2004) The relationship between contact pressure, insert thickness, and mild wear in total knee replacements. Computer Modeling in Engineering & Sciences 6, 145-152.
(Download PDF file)

70. Koh, B.I.*, Reinbolt, J.A.*, Fregly, B.J.†, and George, A.D. (2004) Evaluation of parallel decomposition methods for biomechanical optimizations. Computer Methods in Biomechanics and Biomedical Engineering 7, 215-225.
(Download PDF file)

71. Fregly, B.J.†, Bei, Y.*, and Sylvester, M.E.* (2003) Experimental evaluation of an elastic foundation model to predict contact pressures in knee replacements. Journal of Biomechanics 36, 1659-1668.
(Download PDF file)

72. Fregly, B.J.† and Sawyer, W.G. (2003) Estimation of discretization errors in contact pressure measurements, Journal of Biomechanics 36, 609-613.
(Download PDF file)

73. Sawyer, W.G.†, Hamilton, M.A., Fregly, B.J., and Banks, S.A. (2003) Temperature modeling in a total knee joint replacement using patient-specific kinematics. Tribology Letters 15, 343-351.
(Download PDF file)

74. Hansen E.A.†, Jorgensen L.V., Jensen K., Fregly B.J., Sjogaard G. (2002) Crank inertial load affects freely chosen pedal rate during cycling. Journal of Biomechanics 35, 277-285.
(Download PDF file)

75. Fregly, B.J.†, Zajac, F.E., and Dairaghi, C. A. (2000) Bicycle drive system dynamics: theory and experimental validation. Journal of Biomechanical Engineering 122, 446-452.
(Download PDF file)

76. Chèze, L.†, Fregly, B.J., and Dimnet, J. (1998) Determination of joint functional axes from noisy marker data using the finite helical axis. Human Movement Science 17, 1-15.
(Download PDF file)

77. Fregly, B.J. and Zajac, F.E.† (1996) A state-space analysis of mechanical energy generation, absorption, and transfer during pedaling. Journal of Biomechanics 29, 81-90.
(Download PDF file)

78. Fregly, B.J., Zajac, F.E.†, and Dairaghi, C.A. (1996) Crank inertial load has little effect on steady-state pedaling coordination. Journal of Biomechanics 29, 1559-1567.
(Download PDF file)

79. Chèze, L., Fregly, B.J., and Dimnet, J.† (1995) A solidification procedure to facilitate kinematic analyses based on video system data. Journal of Biomechanics 28, 879-884.
(Download PDF file)

Conference Papers

1. Bianco, N.A., Patten, C., and Fregly, B.J. (2015) Can measured muscle synergies reconstruct unmeasured muscle excitations? Winner of the B.S. student paper competition. Proceedings of the Summer Biomechanics, Bioengineering and Biotransport Conference, June 17-20, Snowbird, Utah.

2. Churchwell, E., Roper, J., Terza, M., Roemmich, R., Fregly, B.J., and Hass, C.J. (2015) Differences in synergistic control of muscles during treadmill walking in anterior cruciate ligament reconstructed legs. Proceedings of the 39th Annual Meeting of the American Society of Biomechanics, August 5-8, Colombus, OH.

3. De Groote, F., Kinney, A.L., and Fregly, B.J. (2015) Evaluation of different optimal control problem formulations for solving the muscle redundancy problem. Proceedings of the XV International Symposium on Computer Simulation in Biomechanics, July 9-11, Edinburgh, Scotland.

4. Eskinazi, I. and Fregly, B.J. (2015) An open-source toolbox for surrogate modeling of joint contact mechanics. Proceedings of the Summer Biomechanics, Bioengineering and Biotransport Conference, June 17-20, Snowbird, Utah.

5. Eskinazi, I. and Fregly, B.J. (2015) An open-source toolbox for surrogate modeling of joint contact mechanics. Proceedings of the XV International Symposium on Computer Simulation in Biomechanics, July 9-11, Edinburgh, Scotland.

6. Fregly, B.J. (2015) Keynote lecture: Design of optimal treatments for walking impairments using neuromusculoskeletal models. Proceedings of Northwest Biomechanics Symposium, May 1-2, Seattle, WA.

7. Fregly, B.J. (2015) Keynote lecture: Design of optimal treatments for walking impairments using multibody dynamic models. Proceedings of the European Community on Computational Methods in Applied Sciences (ECCOMAS) Thematic Conference on Multibody Dynamics, June 29-July 2, Barcelona, Spain.

8. Fregly, B.J. and Rao, A.V. (2015) Optimal Control Workshop. Proceedings of the XV International Symposium on Computer Simulation in Biomechanics, July 9-11, Edinburgh, Scotland.

9. Kinney, A.L. and Fregly, B.J. (2015) Development of a muscle model parameter calibration method via passive muscle force minimization. Proceedings of the XXV Congress of the International Society of Biomechanics, July 12-15, Glascow, Scotland.

10. Meyer, A.J., Patten, C., and Fregly, B.J. (2015) Subject-specific calibration of geometric neuromusculoskeletal models. Proceedings of the XV International Symposium on Computer Simulation in Biomechanics, July 9-11, Edinburgh, Scotland.

11. Meyer, A.J., Patten, C. and Fregly, B.J. (2015) Subject-specific calibration of geometric neuromusculoskeletal models. Finalist in the Ph.D. student paper competition. Proceedings of the Summer Biomechanics, Bioengineering and Biotransport Conference, June 17-20, Snowbird, Utah.

12. Sauder, N.R., Coburn, J.C., Harman, M.K., Vincent, H.K., D’Lima, D.D., and Fregly, B.J. (2015) Do external load measures predict knee contact force changes due to weight loss? Proceedings of the Summer Biomechanics, Bioengineering and Biotransport Conference, June 17-20, Snowbird, Utah.

13. Serrancolí, G., Kinney, A.L., Fregly, B.J., and Font-Llagunes, J.M. (2015) Can a well-calibrated neuromusculoskeletal model predict knee contact forces accurately over multiple walking cycles? Proceedings of the XV International Symposium on Computer Simulation in Biomechanics, July 9-11, Edinburgh, Scotland.

14. Serrancolí, G., Kinney, A.L., Fregly, B.J., and Font-Llagunes, J.M. (2015) How do in vivo knee contact force data affect calibration of muscle-tendon model parameter values? Proceedings of the VI International Conference on Computational Bioengineering, September 14-16, Barcelona, Spain.

15. Serrancolí, G., Kinney, A.L., Fregly, B.J., and Font-Llagunes, J.M. (2015) Prediction of knee contact forces based on synergy-based two-level optimization. Finalist in the Ph.D. student paper competition. Proceedings of the European Community on Computational Methods in Applied Sciences (ECCOMAS) Thematic Conference on Multibody Dynamics, June 29-July 2, Barcelona, Spain.

16. Serrancolí, G., Kinney, A.L., Fregly, B.J., Font-Llagunes, J.M. (2015) The influence of neuromusculoskeletal model calibration method on predicted knee contact forces during walking. Proceedings of the European Community on Computational Methods in Applied Sciences (ECCOMAS) Thematic Conference on Multibody Dynamics, June 29-July 2, Barcelona, Spain.

17. Serrancolí, G., Kinney, A.L., Fregly, B.J., and Font-Llagunes, J.M. (2015) Synergy-based two-level optimization for predicting knee contact forces during walking. Proceedings of the XXV Congress of the International Society of Biomechanics, July 12-15, Glascow, Scotland.

18. Serrancolí, G., Kinney, A.L., Fregly, B.J., and Font-Llagunes, J.M. (2015) What can knee contact force data teach us about calibration of muscle-tendon model parameter values? Proceedings of the Summer Biomechanics, Bioengineering and Biotransport Conference, June 17-20, Snowbird Resort, Utah.

19. Tse, J., Bohne, W., Tran, L., D’Lima, D.D., Patil, S., Fregly, B.J., Backus, S.I., Krazsewski, A.P., Garrison, G., Kontaxis, A., Lenhoff, M., and Hillstrom, H.J. (2015) Effect of knee bracing and wedged insoles upon knee joint contact forces. Proceedings of the 39th Annual Meeting of the American Society of Biomechanics, August 5-8, Colombus, OH.

20. Tse, J., Tran, L., D’Lima, D.D., Patil, S., Fregly, B.J., Backus, S.I., Krazsewski, A.P., Garrison, G., Kontaxis, A., Lenhoff, M., and Hillstrom, H.J. (2015) Biomechanical dosage effect of knee braces on internal joint moment as measured by the e-tibia. Proceedings of the XXV Congress of the International Society of Biomechanics, July 12-15, Glascow, Scotland.

21. Tse, J., Tran, L., D’Lima, D.D., Patil, S., Fregly, B.J., Backus, S.I., Krazsewski, A.P., Garrison, G., Kontaxis, A., Lenhoff, M., and Hillstrom, H.J. (2015) Valgus/varus knee bracing: effects of biomechanical dosage on joint forces. Proceedings of the Gait and Clinical Movement Analysis Society, March 18-21, Portland, OR.

22. Bianco, N.A.*, Kinney, A.L.*, and Fregly, B.J. (2014) Predicting unmeasured muscle excitations from measured muscle synergies. Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

23. Eskinazi, I.*, Rao, A.V., and Fregly, B.J. (2014) Minimizing OpenSim state derivative computational cost for optimal control applications. Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

24. Fregly, B.J., Kinney, A.L.*, Besier, T.F., and D’Lima, D.D. (2014) How has the Knee Grand Challenge improved musculoskeletal modeling research? Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

25. Fregly, C.D.§, Kim, B.T.§, De Witt, J.K., and Fregly, B.J. (2014) Model-based recommendations for reducing back loads during squat exercise on the International Space Station. Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

26. Kinney, A.L.*, Rao, A.V., and Fregly, B.J. (2014) Feasibility tuning to improve optimization prediction of knee contact forces. Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

27. Meyer, A.J.*, Jackson, J.J.*, Patterson, M.A., Rao, A.V., and Fregly, B.J. (2014) Generating three-dimensional dynamically consistent simulations of walking using optimal control. Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

28. Pai, M.*, Patten, C., and Fregly, B.J. (2014) Synergy analysis of pre-treatment EMG differentiates responders and non-responders to stroke rehabilitation. Proceedings of the 7th World Congress of Biomechanics, July 6-11, Boston, MA.

29. Tran, L., Tse, J., Chao, K., Minacori, R., Kirane, Y., Steklov, N., Patil, S. Fregly, B.J., D’Lima, D.D., Garrison, G., Bido, J., Lenhoff, M., Backus, S., Kraszewski, A., Kontaxis, A., and Hillstron, H. (2014) Effect of valgus knee bracing on medial and lateral compartment loading during stair descent. Proceedings of the Gait and Clinical Movement Analysis Society, June 24-28, Newark, DE.

30. Tran, L., Tse, J., Chao, K., Minacor, R., Kirane, Y., Steklov, N., Patil, S., Fregly, B.J., D'Lima, D.D., Lenhoff, M., Backus, S., Kraszewski, A., Kontaxis, A., and Hillstrom, H. (2014) Effect of knee bracing on knee joint contact mechanics during stair descent. Proceedings of the 60th Annual Meeting Orthopaedic Research Society, March 15-18, New Orleans, LA.

31. Eskinazi, I.* and Fregly, B.J. (2013) Surrogate knee contact modeling using artificial neural networks. Proceedings of the ASME Summer Bioengineering Conference, June 26-29, Sunriver, OR.

32. Fregly, B.J., Walter, J.P*, Kinney, A.L.*, Banks, S.A., D’Lima, D.D., Besier, T.F., and Lloyd, D.G. (2013) Muscle synergies improve estimation of knee contact forces during walking. Proceedings of the 11th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, April 3-7, Salt Lake City, UT.

33. Fregly, B.J., Walter, J.P*, Kinney, A.L.*, Banks, S.A., D’Lima, D.D., Besier, T.F., and Lloyd, D.G. (2013) Muscle synergy constraints improve prediction of knee contact forces during gait. Proceedings of the ASME Summer Bioengineering Conference, June 26-29, Sunriver, OR.

34. Fregly, B.J., Walter, J.P*, Kinney, A.L.*, Banks, S.A., D’Lima, D.D., Besier, T.F., and Lloyd, D.G. (2013) Synergy controls improve prediction of knee contact forces and muscle excitations during gait. Proceedings of the XIV International Symposium on Computer Simulation in Biomechanics, August 1-3, Natal, Brazil.

35. Fregly, C.D.§, Kim, B.T.§, De Witt, J.K., and Fregly, B.J. (2013) Dynamic simulation of muscle loading during ARED squat exercise on the International Space Station. Proceedings of the ASME Summer Bioengineering Conference, June 26-29, Sunriver, OR. (This high school science fair project received a Recognition Award at the 2013 Florida State Science Fair in the Medicine and Health category).

36. Higa, M., Fregly, B.J., Tanino, H., Ito, H. Abo, M., Kakunai, S., and Banks, S.A. (2013) Predicting patient-specific muscle parameters of the hip with osteoarthritis. Proceedings of the 59th Annual Meeting Orthopaedic Research Society, January 26-29, San Antonio, TX.

37. Jackson, J.N.*, Hass, C.J., and Fregly, B.J. (2013) Development of a subject-specific foot-ground contact model to predict all six ground reaction components. Proceedings of the ASME Summer Bioengineering Conference, June 26-29, Sunriver, OR.

38. Kinney, A.L.*, Vincent, H.K., Harman, M.K., Coburn, J., D’Lima, D.D., and Fregly, B.J. (2013) Effects of body weight modification on internal knee contact forces during gait. Proceedings of the ASME Summer Bioengineering Conference, June 26-29, Sunriver, OR.

39. Meyer, A.J.*, Patton, C., and Fregly, B.J. (2013) A surrogate model for lower extremity EMG-to-moment estimation during walking. Proceedings of the XIV International Symposium on Computer Simulation in Biomechanics, August 1-3, Natal, Brazil.

40. Meyer, A.J.*, Patton, C., and Fregly, B.J. (2013) A surrogate model for lower extremity EMG-to-moment estimation during walking. Proceedings of the XXIV Congress of the International Society of Biomechanics, August 4-9, Natal, Brazil.

41. Meyer, A.J.*, Patton, C., and Fregly, B.J. (2013) Physiologically consistent EMG-to-moment estimation at the hip, knee, and ankle during gait. Proceedings of the ASME Summer Bioengineering Conference, June 26-29, Sunriver, OR.

42. Minacori, R., Kirane, Y., D’Lima, D.D., Fregly, B.J., Lenhoff, M., Backus, S., Kraszewski, A., Garrison, G., Bido, J., Kontaxis, A., and Hillstrom, H, (2013) In-vivo Biomechanical Effects of Conservative Realignment Bracing: A Case Study. Proceedings of IMechE Knee Surgery and Rehabilitation in 2013: How is Engineering Driving Improved Treatment?, November 11-12, London, England.

43. Serrancolí1, G.*, Walter, J.P.*, Kinney, A.L.*, Fregly, B.J., and Font-Llagunes, J.M. (2013) Optimization problem formulation for predicting knee muscle and contact forces during gait. Proceedings of the XIV International Symposium on Computer Simulation in Biomechanics, August 1-3, Natal, Brazil.

44. Fregly, B.J., Walter, J.P.*, Kinney, A.L.*, Banks, S.A., D’Lima, D.D., Besier, T.F., and Lloyd, D.G. (2013) Muscle synergies improve prediction of knee contact forces during walking. Proceedings of the 11th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, April 3-7, Salt Lake City, UT.

45. Hass, C.J., Rodriguez, K., Roemmich R., Stegemoller, E., Cam, B.*, and Fregly, B. (2012) Persons with Parkinson’s disease exhibit decreased neuromuscular complexity during gait. Proceedings of the Society for Neuroscience, October, October 13-17, New Orleans, LA.

46. Lloyd, D.G., Sartori, M., Gerus, P, Saxby, D., Fregly, B.J., Besier, T.F., Delp, S.L., Banks, S.A., Pandy, M.G., and D’Lima, D.D. (2012) Computational neuromusculoskeletal modelling to examine tissue loading in humans. Plenary lecture, Proceedings of the 6th European Congress on Computational Methods in Applied Sciences and Engineering, September 10-14, Vienna, Austria.

47. Gerus, P., Lloyd, D.G., Sartori, M., Fregly, B.J., Besier, T.F., Delp, S.L., Banks, S.A., Pandy, M.G., and D’Lima, D.D. (2012) Using subject-specific bones and implant geometry improves the accuracy in estimating the joint contact forces at the knee medial and lateral condyles. Proceedings of the 6th European Congress on Computational Methods in Applied Sciences and Engineering, September 10-14, Vienna, Austria.

48. Hall, A.L.*, Besier, T.F., Silder, A., Delp, S.L., D’Lima, D.D., and Fregly, B.J. (2012) Changes in in vivo knee contact force through gait modification. Proceedings of the 36th Annual Meeting of the American Society of Biomechanics, August 15-18, Gainesville, FL.

49. Jackson, J.N.*, Hass, C.J, and Fregly, B.J. (2012) Development of a subject-specific vertical ground contact force model. Proceedings of the 36th Annual Meeting of the American Society of Biomechanics, August 15-18, Gainesville, FL.

50. Jackson, J.N.*, Hass, C.J, and Fregly, B.J. (2012) Residual elimination algorithm improvements for forward dynamic simulation of gait. Proceedings of the 36th Annual Meeting of the American Society of Biomechanics, August 15-18, Gainesville, FL.

51. Li, Lingmin*, Patil, S., Steklov, N., Bae, W., D’Lima, D.D., Sah, R.L., and Fregly, B.J. (2012) Predicting in vitro articular cartilage wear in the patellofemoral joint using finite element modeling. Proceedings of the 36th Annual Meeting of the American Society of Biomechanics, August 15-18, Gainesville, FL.

52. Meyer, A.J.*, D’Lima, D.D., Banks, S.A., Lloyd, D.G., Besier, T.F., Colwell, C.W., and Fregly, B.J. (2012) Are external knee load and EMG measures strong indicators of internal knee contact forces during gait? Proceedings of the 36th Annual Meeting of the American Society of Biomechanics, August 15-18, Gainesville, FL.

53. Meyer, A.J.*, Patten, C., and Fregly, B.J. (2012) A novel statistical method for EMG-to-moment estimation during gait. Proceedings of the 36th Annual Meeting of the American Society of Biomechanics, August 15-18, Gainesville, FL.

54. Fregly, C.D.§, Kim, B.T.§, Li, Z.§, De Witt, J.K., and Fregly, B.J. (2012) Estimated muscle loads during squat exercise in microgravity conditions. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico. (This middle school science fair project, which took second place at the 2012 Florida State Science Fair in the Medicine and Health category, was accepted as a podium presentation and was presented at the conference by the first two authors).

55. Hall, A.L.*, Besier, T.F., Silder, A., Delp, S.L., D’Lima, D.D., and Fregly, B.J. (2012) Changes in medial knee contact force through gait modification. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico.

56. Hall, A.L.*, Walter, J.P.*, Besier, T.F., Silder, A., Delp, S.L., D’Lima, D.D., and Fregly, B.J. (2012) Experimental evaluation of computationally predicted changed in knee loads resulting from medial thrust gait. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico.

57. Jackson, J.N.*, Hass, C.J., and Fregly, B.J. (2012) Residual elimination algorithm enhancements to improve foot motion tracking during forward dynamic simulation of gait. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico.

58. Li, L.*, Patil, S., Steklov, N., Bae, W., D’Lima, D.D., Sah, R.L., and Fregly, B.J. (2012) Finite element modeling of in vitro articular cartilage wear in the patellofemoral joint. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico.

59. Meyer, A.J.*, D’Lima, D.D., Banks, S.A., Lloyd, D.G., Besier, T.F., Colwell, C.W., and Fregly, B.J. (2012) Correlation between in vivo knee contact forces and external measures during gait. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico.

60. Meyer, A.J.*, Patten, C., and Fregly, B.J. (2012) Evaluation of a novel statistical method for EMG-to-moment estimation during gait. Proceedings of the ASME Summer Bioengineering Conference, June 20-23, Fajardo, Puerto Rico.

61. Fregly, B.J. and Patten, C. (2012) Technical-clinical symposium: Model-based stroke rehabilitation case study. Proceedings of the Gait and Clinical Movement Society Annual Meeting, May 9-12, Grand Rapids, MI.

62. Machado, M.*, Flores, P., Walter, J.P.*, and Fregly, B.J. (2012) Challenges in using OpenSim as a multibody design tool to model, simulate, and analyze prosthetic devices: a knee joint case-study. Proceedings of the EUROMECH Colloquium 524: Multibody System Modelling, Control and Simulation for Engineering Design, February 27-March 1, Enschede, the Netherlands.

63. Fregly, B.J., Chmielewski, T.L., Walter, J.P.*, Pun, H., Chan, N.K.*, Moser, M.W., and Vincent, K.R. (2011) Evaluation of a model-based gait retraining method for knee osteoarthritis rehabilitation. Proceedings of the Gait and Clinical Movement Society Annual Meeting, April 26-29, Bethesda, MD.

64. Meyer, A.J.*, D’Lima, D.D., Banks, S.A., Coburn, J., Harman, M., Mikashima, Y., and Fregly, B.J. (2011) Evaluation of regression equations for medial and lateral contact force from instrumented knee implant data. Proceedings of the ASME Summer Bioengineering Conference, June 22-25, Farmington, PA.

65. Walter, J.P.*, D’Lima, D.D., and Fregly, B.J. (2011) Model-based prediction of medial contact force changes due to gait modification. Proceedings of the 13th International Symposium on Computer Simulation in Biomechanics, June 30-July 2, Leuven, Belgium.

66. Walter, J.P.*, D’Lima, D.D., Besier, T.P., and Fregly, B.J. (2011) Feasibility of highly constrained muscle force predictions for the knee during gait. Proceedings of the ASME Summer Bioengineering Conference, June 22-25, Farmington, PA.

67. Walter, J.P.*, D’Lima, D.D., and Fregly, B.J. (2011) Model-based prediction of medial contact force changes due to gait modification. Proceedings of the 13th International Symposium on Computer Simulation in Biomechanics, Leuven, Belgium.

68. Fregly, B.J., Chmielewski, T.L., Walter, J.P.*, Pun, H.*, Chan, N.K., Moser, M.W., and Vincent, K.R. (2011) Evaluation of a model-based gait retraining method for knee osteoarthritis. Proceedings of the Annual Meeting of the Gait and Clinical Movement Analysis Society, April 26-29, Bethesda, MD.

69. Meyer, A.J.*, D’Lima, D.D., Banks, S.A., Coburn, J., Harman, M., Mikashima, Y, and Fregly, B.J. (2011) Evaluation of regression equations for medial and lateral contact force from instrumented knee implant data. Proceedings of the ASME Summer Bioengineering Conference, June 22-25, Farmington, PA.

70. Walter, J.P.*, D’Lima, D.D., and Fregly, B.J. (2011) Feasibility of highly constrained muscle force predictions for the knee during gait. Proceedings of the ASME Summer Bioengineering Conference, June 22-25, Farmington, PA.

71. Jackson, J.N.*, Hass, C.J., DeWitt, J.K., Walter, J.P.*, and Fregly, B.J. (2010) Variation of whole-body angular and linear momentum during locomotion. Proceedings of the ASME Summer Bioengineering Conference, June 16-19, Naples, FL.

72. Li, L.*, Patil, S., Steklov, N., Bae, W., Temple-Wong, M., D’Lima, D.D., Sah, R.L., and Fregly, B.J. (2010) Computational simulation of articular cartilage wear in the patellofemoral joint during in vitro testing. Proceedings of the ASME Summer Bioengineering Conference, June 16-19, Naples, FL.

73. Meyer, A.J.*, D’Lima, D.D., Banks, S.A., Coburn, J., Harman, M., and Fregly, B.J. (2010) Estimation of pose and medial/lateral contact force using multi-axial load measurements from an instrumented knee implant. Proceedings of the ASME Summer Bioengineering Conference, June 16-19, Naples, FL.

74. Walter, J.P.*, D’Lima, D.D., and Fregly, B.J. (2010) Muscle forces may explain paradoxical knee loads during different gait patterns. Proceedings of the ASME Summer Bioengineering Conference, June 16-19, Naples, FL.

75. Fregly, B.J., Lin, Y.C.*, Walter, J.P.*, Fernandez, J.W., Banks, S.A., and Pandy, M.G. (2009) Simultaneous prediction of muscle and contact forces in the knee during gait. Proceedings of the ASME Summer Bioengineering Conference, June 17-21, Lake Tahoe, CA.

76. Fregly, B.J., Lin, Y.C.*, Walter, J.P.*, Pandy, M.G., Banks, S.A., and D’Lima, D.D. (2009) Muscle and contact contributions to inverse dynamic knee loads during gait. Proceedings of the ASME Summer Bioengineering Conference, June 17-21, Lake Tahoe, CA.

77. Walter, J.P.*, D’Lima, D.D., and Fregly, B.J. (2009) Decreased knee adduction moment does not guarantee decreased medial contact force during gait. Proceedings of the ASME Summer Bioengineering Conference, June 17-21, Lake Tahoe, CA.

78. Walter, J.P*, Pun, H.*, Chan, N., Chmielewski, T.L., and Fregly, B.J. (2009) Real-time model-based gait retraining for knee osteoarthritis rehabilitation. Proceedings of the ASME Summer Bioengineering Conference, June 17-21, Lake Tahoe, CA.

79. Fregly, B.J., Lin, Y.C.*, Walter, J.P.*, Banks, S.A., Pandy, M.G., and D’Lima, D.D. (2009) Muscle and contact contributions to inverse dynamic knee loads during gait. Knee Arthroplasty: From Early Intervention to Revision Conference, April 27-May 2, London, England.

80. Whatling, G.M., Ozturk, H., Pierron, F., Larcher, M., Young, P., Evans, J., Jones, D., Banks, S.A., Fregly, B.J., and Holt, C.A. (2009) A study of the errors associated with measuring knee kinematics using marker based motion capture and imaging. Knee Arthroplasty: From Early Intervention to Revision Conference, April 27-May 2, London, England.

81. Pineda, L., Fregly, B.J., Haftka, R.T., and Queipo, N.V. (2009) Assessing the validity of surrogate models with restricted input spaces. Proceedings of the 8th World Congress on Structural and Multidisciplinary Optimization, June 1-5, Lisbon, Portugal.

82. Whatling, G.M., Ozturk, H., Pierron, F., Larcher, M., Young, P., Evans, J., Jones, D., Banks, S.A., Fregly, B.J., and Holt, C.A. (2008) Fusing marker- based motion capture with image registration to study the errors associated with quantifying knee kinematics. Proceedings of the Tenth International Symposium on the 3-D Analysis of Human Movement, October 28-31, Santpoort-Amsterdam, Netherlands.

83. Jackson, J.N.*, Walter, J.P.*, DeWitt, J.K., and Fregly, B.J. (2008) Effects of external loading on optimization predictions of vertical ground reaction forces during 0g walking. Proceedings of the 16th International Conference of Mechanics in Medicine and Biology, July 23-25, Pittsburgh, PA.

84. Fattey, M.G.* and Fregly, B.J. (2008) Simultaneous determination of skeletal model parameter values, motions, and controls from noisy measurement data. Proceedings of the ASME Summer Bioengineering Conference, SBC2008-192605, June 25-29, Marco Island, FL.

85. Fernandez, J.W., Kim, H.J., Akbarshahi, M., Walter, J.P.*, Fregly, B.J., and Pandy, M.G. (2008) Evaluation of predicted knee joint muscle forces during gait using an instrumented knee implant. Proceedings of the ASME Summer Bioengineering Conference, SBC2008-191839, June 25-29, Marco Island, FL.

86. Lin, Y.C.*, Haftka, R.T., Queipo, N.V., and Fregly, B.J. (2008) Dynamic simulation of knee motion using three-dimensional surrogate contact modeling. Proceedings of the ASME Summer Bioengineering Conference, SBC2008-190966, June 25-29, Marco Island, FL.

87. Walter, J.P.*, Banks, S.A., D’Lima, D.D., and Fregly, B.J. (2008) Prediction of internal contact forces at the knee from external measurements. Proceedings of the ASME Summer Bioengineering Conference, SBC2008-193169, June 25-29, Marco Island, FL.

88. Fregly, B.J., D’Lima, D.D., and Colwell, C.W. (2008) Effective gait modification strategies for offloading the medial compartment of the knee. Proceedings of the ASME Summer Bioengineering Conference, SBC2008-192701, June 25-29, Marco Island, FL.

89. Fregly, B.J. (2008) Effect of foot path alterations on adduction moment reductions produced by knee medialization during gait. Proceedings of the 13th Annual Meeting of the Gait and Clinical Movement Analysis Society, April 2-5, Richmond, Virginia.

90. Fregly, B.J., Banks, S.A., D’Lima, D.D., and Colwell, C.W. (2007) Sensitivity of knee replacement contact conditions to kinematic measurement errors. Proceedings of the XXI Congress of the International Society of Biomechanics, July 1-5, Taipei, Taiwan.

91. Fregly, B.J., Crossley, K., Hinman, R., and Schache, A. (2007) Evaluation of a medial-thrust gait pattern to reduce the peak knee adduction torque. Proceedings of the XXI Congress of the International Society of Biomechanics, July 1-5, Taipei, Taiwan.

92. Lin, Y.-C.*, Haftka, R.T., Queipo, N.V., and Fregly, B.J. (2007) Sensitivity of knee simulator machine wear volume to variations in motion and load inputs and component placements. Proceedings of the XXI Congress of the International Society of Biomechanics, July 1-5, Taipei, Taiwan.

93. Moro-oka, T., Hamai, S., Miura, H., Higaki, H., Shimoto, T., Fregly, B.J., Iwamoto, Y., and Banks, S.A. (2007) Dynamic activity dependence of normal knee kinematics in vivo. Proceedings of the 53rd Annual Meeting of the Orthopaedic Research Society, February 11-14, San Diego, CA.

94. DiGiovanna, J., Sanchez, J.C., Fregly, B.J., and Principe, J.C. (2006) Arm motion reconstruction via feature clustering in joint angle space. Proceedings of the International Joint Conference on Neural Networks, July 16-21, pp. 4678 - 4683, Vancouver, Canada.

95. Fregly, B.J. and Reinbolt, J.A.* (2006) Simulation-based treatment planning for knee osteoarthritis. Proceedings of the 30th Annual Meeting of the American Society of Biomechanics, September 6-9, Blacksburg, VA (Invited panelist presentation for special symposium on Clinical Application of Modeling in Biomechanics).

96. Zhao, D.*, Banks, S.A., Mitchell, K., D’Lima, D., Colwell, C., and Fregly, B.J. (2006) The relationship between the knee adduction torque and medial contact force during gait. Proceedings of the 5th World Congress of Biomechanics, July 29-August 4, Munich, Germany.

97. Lin, Y.-C.*, Haftka, R.T., Queipo, N.V., and Fregly, B.J. (2006) A generalized surrogate contact model for dynamic simulations with anatomic joints. Proceedings of the ASME Summer Bioengineering Conference, June 21-25, Amelia Island, Florida.

98. Marquez-Barrientos, C.*, Banks, S.A., and Fregly, B.J. (2006) The influence of sagittal and coronal conformity on predicted wear volume in total knee replacement design. Proceedings of the ASME Summer Bioengineering Conference, June 21-25, Amelia Island, Florida.

99. Reinbolt, J.A.* and Fregly, B.J. (2006) Benefits of automatic differentiation for biomechanical optimizations. Proceedings of the ASME Summer Bioengineering Conference, June 21-25, Amelia Island, Florida.

100. Zhao, D.*, Banks, S.A., Mitchell, K., D’Lima, D., Colwell, C., and Fregly, B.J. (2006) The relationship between the knee adduction torque and medial contact force during gait. Proceedings of the ASME Summer Bioengineering Conference, June 21-25, Amelia Island, Florida.

101. Zhao, D.*, Sakoda, H., Sawyer, W.G., Banks, S.A., and Fregly, B.J. (2006) Can pin-on-plate tests be used to predict joint-level wear in knee replacements? In Proceedings of the ASME Summer Bioengineering Conference, June 21-25, Amelia Island, Florida.

102. Fregly, B.J., Reinbolt, J.A.*, Rooney, K.L.*, Mitchell, K.H., and Chmielweski, T.L. (2006) Predicting patient-specific gait modifications for knee osteoarthritis rehabilitation. Proceedings of the 7th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, manuscript 174, Juan-les-Pins, France.

103. Fregly, B.J., Reinbolt, J.A.*, Koh, B.I.*, and Chmielweski, T.L. (2006) Evaluation of a patient-specific cost function to predict the influence of foot path on the knee adduction torque during gait . Proceedings of the 7th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, manuscript 173, Juan-les-Pins, France.

104. Lin, Y.C.*, Haftka, R.T., Queipo, N.V., and Fregly, B.J. (2006) A generalized analytical joint contact model for dynamic musculoskeletal simulations. Proceedings of the 7th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, manuscript 172, Juan-les-Pins, France.

105. Banks, S.A., Zhao, D.*, Fregly B.J., D’Lima, D.D., and Colwell, C.W. (2006) Can fluoroscopically derived kinematics be used to infer coronal knee loads? In Proceedings of the 52nd Annual Meeting of the Orthopaedic Research Society, p. 556, Chicago, IL.

106. Zhao, D.*, Fregly, B.J., Mitchell, K., D’Lima, D.D., Colwell, C.W., and Banks, S.A. (2006) Sensitivity of joint contact model predictions to imperfectly synchronized motion data inputs. Proceedings of the 52nd Annual Meeting of the Orthopaedic Research Society, p. 590, Chicago, IL.

107. Zhao, D.*, Fregly, B.J., Banks, S.A., D’Lima, D.D., and Colwell, C.W. (2006) In vivo medial and lateral tibial loads during gait, stair, kneel, and lunge activities. Proceedings of the 52nd Annual Meeting of the Orthopaedic Research Society, p. 277, Chicago, IL.

108. Banks, S.A., Fregly, B.J., Harman, M.K., Hamilton, M.A., and Sawyer, W.G. (2005) Objective lifetime design of orthopaedic joint replacements: Are we there yet? In Proceedings of the World Tribology Congress III, p 651-652, Washington, DC.

109. Fregly, B.J., Rooney, K.L.*, and Reinbolt, J.A.* (2005) Predicted gait modifications to reduce the peak knee adduction torque. Proceedings of the XXth Congress of the International Society of Biomechanics, p. 283, Cleveland, OH.

110. Koh, B.-I.*, Fregly, B.J., George, A.D., and Haftka, R.T. (2005) Parallel asynchronous particle swarm for global biomechanical optimization. Proceedings of the 10th International Symposium on Computer Simulation in Biomechanics, pp. 86-87, Cleveland, OH.

111. Lin, Y.-C.*, Fregly, B.J., Haftka, R.T., and Queipo, N.V. (2005) Surrogate-based contact modeling for efficient dynamic simulation with deformable anatomic joints. Proceedings of the 10th International Symposium on Computer Simulation in Biomechanics, pp. 23-24, Cleveland, OH.

112. Reinbolt, J.A.* and Fregly, B.J. (2005) Creation of patient-specific dynamic models from three-dimensional movement data using optimization. Proceedings of the 10th International Symposium on Computer Simulation in Biomechanics, pp. 11-12, Cleveland, OH.

113. Zhao, D.*, Fregly, B.J., Banks, S.A., D’Lima, D.D., and Colwell, C.W. (2005) Computational determination of in vivo medial and lateral tibial forces during gait. Proceedings of the 10th International Symposium on Computer Simulation in Biomechanics, pp. 53-54, Cleveland, OH.

114. Zhao, D.*, Fregly, B.J., and Sawyer, W.G. (2005) Dynamic simulation of a simulator machine for knee implant damage prediction. Proceedings of the IMechE Knee Arthroplasty Technology Conference, pp. 237-240, London, England.

115. Zhao, D.*, Sawyer, W.G., and Fregly, B.J. (2005) Computational wear prediction of UHMWPE in knee replacements. Proceedings of the ASTM Conference on Medical and Surgical Materials and Devices, Winner of the Student Paper Competition sponsored by ASTM International Committee F04 on Medical and Surgical Materials and Devices, Dallas, TX.

116. Fregly, B.J. and Reinbolt, J.A.* (2004) Estimation of body segment parameters from three-dimensional gait data using optimization. Proceedings of the Eighth International Symposium on the 3D Analysis of Human Movement, pp. 13-16, Tampa, FL.

117. Koh, B.I.*, Reinbolt, J.A.*, Fregly, B.J., and George, A.D. (2004) Parallel decomposition methods for biomechanical optimization. Proceedings of the Eighth International Symposium on the 3D Analysis of Human Movement, pp. 69-72, Tampa, FL.

118. Kolb, E., Cole, B.J., Berkson, E., Garretson, R., Farr, J., and Fregly B. (2004) The effects of medial meniscal transplantation techniques on intra-articular contact pressures. Proceedings of the 71st Annual Meeting of the American Academy of Orthopedic Surgeons, San Francisco, CA, March 10-14.

119. Lin, Y.-C.* and Fregly, B.J. (2004) Experimental evaluation of a three-dimensional knee contact model using response surface optimization. Proceedings of the Eighth International Symposium on the 3D Analysis of Human Movement, pp. 29-32, Tampa, FL.

120. Rooney, K.* and Fregly, B.J. (2004) An inverse dynamics optimization approach for predicting human movement. Proceedings of the Eighth International Symposium on the 3D Analysis of Human Movement, pp. 85-88, Tampa, FL.

121. Banks, S.A., Fregly, B.J., Reinschmidt, C., Boniforti, F., and Romagnoli, S. (2004) In vivo gait and stair kinematics in patients with uni- and bi-unicondylar knee arthroplasty. of unicondylar and bi-unicondylar knee replacements. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, p. 243, San Francisco, CA.

122. Bei, Y.*, Fregly, B.J., Sawyer, W.G., and Banks, S.A. (2004) Predicted sensitivity of knee implant wear to insert thickness and body mass. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, p. 1465, San Francisco, CA.

123. Fregly, B.J., Rahman, H.*, and Banks, S.A. (2004) An automated image matching procedure for measuring natural knee kinematics with single-plane fluoroscopy. Transactions of the 50th Annual Meeting of the Orthopaedic Research Society, p. 86, San Francisco, CA.

124. Fregly, B.J., Sawyer, W.G., Harman, M.K., and Banks, S.A. (2003) Computational prediction of in vivo wear in total knee replacements. Proceedings of the ASME Summer Bionengineering Conference, June 25-29, pp. 1171-1172, Key Biscayne, Florida.

125. Rahman, H.*, Fregly, B.J., and Banks, S.A. (2003) Accurate measurement of three-dimensional natural knee kinematics using single-plane fluoroscopy. Proceedings of the ASME Summer Bionengineering Conference, June 25-29, pp. 465-466, Key Biscayne, Florida

126. Reinbolt, J.A.*, Schutte, J.F.*, Haftka, R.T., George, A.D., Mitchell, K.H., and Fregly, B.J. (2003) Determination of patient-specific functional axes through two-level optimization. Proceedings of the ASME Summer Bionengineering Conference, June 25-29, pp. 317-318, Key Biscayne, Florida

127. Sawyer, W.G., Hamilton, M.A., Sucec, M.C., Fregly, B.J., and Banks, S.A. (2003) Analysis of in vivo crossing motion in total knee replacements. Proceedings of the ASME Summer Bionengineering Conference, June 25-29, pp. 549-550, Key Biscayne, Florida

128. Schutte, J.F.*, Koh, B.*, Reinbolt, J.A.*, Haftka, R.T., George, A.D., and Fregly, B.J. (2003) Scale-independent biomechanical optimization. Proceedings of the ASME Bionengineering Conference, June 25-29, pp. 55-56, Key Biscayne, Florida

129. Schutte, J.F.*, Fregly, B.J., Haftka, R.T., and George, A. (2003) A parallel particle swarm algorithm. Proceedings of the Fifth World Congress of Structural and Multidisciplinary Optimization, Venice, Italy.

130. Banks, S.A., Boniforti, F, Fregly, B.J., Rahman, H.*, Reinschmidt, C., and Romagnoli, S. (2003) The kinematics of deep flexion in bi-cruciate retaining resurfacing knee arthroplasty. Transactions of the 49th Annual Meeting of the Orthopaedic Research Society, p. 1323, New Orleans, LA.

131. Fregly, B.J. (2000) Effect of femoral component malrotation on contact stress in total knee replacements. Proceedings of the 24th Annual Meeting of the American Society of Biomechanics, pp. 101-102, University of Illinois at Chicago, Chicago, IL.

132. Fregly, B.J. (1999) A three-dimensional compliant contact model for dynamic simulation of total knee replacements. Proceedings of the VIIth International Symposium on Computer Simulation in Biomechanics, pp. 10-13, University of Calgary, Calgary, Alberta, Canada.

133. Fregly, B.J. (1997) A measurement procedure to reduce pedaling inverse dynamics errors due to linkage model inaccuracies. Proceedings of the ASME Summer Bioengineering Conference, June 11-15, pp. 449-450, Sun River, Oregon.

134. Fregly, B.J. and Whalen, R.T. (1995) Simulated changes in control strategy during altered gravity pedaling. Proceedings of the 19th Annual Meeting of the American Society of Biomechanics, pp. 67-68, Stanford University, Stanford, CA.